Upperton, a contract development and manufacturing organization (CDMO) based in Nottingham, UK, has increased its high precision filling capability with the installation and commission of a Fill2Weight gravimetric powder filling machine from 3P innovation.

The system has been installed at Upperton’s 60,000-square-foot GMP facility in Nottingham, UK, which supports formulation development and clinical manufacturing across a broad range of dosage forms, including oral solids, nasal, pulmonary and parenteral.

The Fill2Weight system enables high precision and efficiency in capsule or device filling through its gravimetric dosing mechanism. This ensures consistent weight verification for each capsule, making it ideal for low-dose and high-potency active pharmaceutical ingredients (APIs), as well as challenging powder formulations.

The technology also supports working with limited-quantity APIs and offers versatility for a wide range of powder types and fill weights, for oral (capsules), nasal and pulmonary including dry-powder inhalers.

Ian Lafferty, Chief Technical Officer at Upperton, said: “This addition marks a significant advancement in our GMP manufacturing capabilities, increasing our capacity to manufacture small-molecule and high potency medicines for clinical trials.”