Piramal Pharma Solutions, a global Contract Development and Manufacturing Organization (CDMO) and part of Piramal Pharma Ltd., has introduced a tablet-in-capsule drug delivery system at its drug product facilities in Pithampur and Ahmedabad, India. With expanded tablet-in-capsule capabilities now in its toolkit, Piramal can offer partners and patients more flexible and customizable dosing options for critical oral drug therapies, including modified release drug delivery.

The project was initiated at the Piramal Pharmaceutical Development Services (PPDS) site in Ahmedabad. Within just five months, the site team completed a successful tech transfer to Piramal’s commercial manufacturing site in Pithampur inclusive of development of the three tablets to be encapsulated.

Tablet-in-capsule technology offers developers a unique solution wherein different active ingredients are formulated into their own separate tablets or minitablets. The tablets are then placed together into a single capsule shell. By applying distinct coatings to minitablets, drug developers can achieve versatile release profiles of the same or different drugs. This approach also allows incompatible active ingredients to be combined into one capsule, providing patients a simplified way to limit dosing frequency and improve medication adherence.

“By enabling dual actives in the same capsule or dual-release profiles within a single capsule, our tablet-in-capsule technology provides unmatched dosing flexibility and release control, accelerating timelines for developers and simplifying dosing for patients,” said Brad Gold, Ph.D., Head of Global Formulations R&D at Piramal Pharma Solutions and Member of Piramal’s Science Collective. “Because each drug is optimized in its own tablet or minitablet, this technology can also enhance formulation stability and medicine personalization.”

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